Increased serum levels of a proliferation-inducing ligand in patients with bullous pemphigoid
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چکیده
منابع مشابه
Increased serum levels of a proliferation-inducing ligand in patients with bullous pemphigoid.
BACKGROUND B cells have been demonstrated to have critical roles in developing autoimmune bullous diseases. Recently identified tumor necrosis factor-like molecules, B cell-activating factor of the TNF family (BAFF) and a proliferation-inducing ligand (APRIL) are essential molecules for B cell development, survival, and proliferation. Although the functions of APRIL have not been fully evaluate...
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متن کاملSerum levels of autoantibodies to BP180 correlate with disease activity in patients with bullous pemphigoid.
BACKGROUND The 180-kDa transmembrane hemidesmosomal protein (BPAG2) has been identified as an important autoantigen in bullous pemphigoid (BP). Using the NC16A domain as the antigenic target, a highly sensitive and specific enzyme-linked immunosorbent assay (ELISA) for the detection of autoantibodies to BP180 was developed. AIM To investigate the correlation of clinical severity and ELISA ind...
متن کاملSerum Levels of Autoantibodies to BP180 Correlate With Disease Activity in Patients With Bullous Pemphigoid
Main Outcome Measures: Disease activity, serum levels of autoantibodies to BP180, and titers of anti– basement membrane zone autoantibodies were assayed before initiation of treatment and 4 and 8 weeks later. Reactivity to BP180 was analyzed by enzyme-linked immunosorbent assay using a recombinant form of BP180 NC16A. Titers of anti–basement membrane zone autoantibodies were assayed by indirect...
متن کاملSerum protein carbonyl and total antioxidant capacity levels in pemphigus vulgaris and bullous pemphigoid
Background: Pemphigus diseases including pemphigus vulgaris (PV) and bullous pemphigoid (BP) are autoimmune diseases that cause severe blistering of the skin and mucous membranes. Among inflammatory mediators, reactive oxygen species (ROS) are involved in the pathogenesis of a wide variety of diseases through oxidative stress for which protein carbonyl (PC) and total antioxidant capacity (TAC) ...
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ژورنال
عنوان ژورنال: Journal of Dermatological Science
سال: 2007
ISSN: 0923-1811
DOI: 10.1016/j.jdermsci.2006.12.008